Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Scientist Solid Tumor CAR as part of the Research & Early Development team based in Philadelphia, PA.

Role Overview

This position will join a new interdisciplinary team focusing on the development of Legend's engineered cell therapy platform for treating solid tumor.

Qualified candidates should have hands on experience working with CAR-T and/or other engineered immune cell types for solid tumor cell therapy discovery.

The ideal candidate should be driven, analytical, thoughtful and creative, who can function both independently and collaboratively in a fast-paced environment.

This position will initially report to Senior Director of Research. Location: Philadelphia.

Key Responsibilities

Design and execute CAR-T cell functional assays.
Design strategies to address target-expression heterogeneity for novel CAR design.
Develop in vitro assays to assess CAR-T cell bystander killing and antigen-spreading.
Analyze and interpret data, troubleshooting, present to and engage internal stakeholders
Stay abreast of the latest advancement of cell therapy in solid tumor. Develop relevant insight in selected disease area.

Requirements

Scientist- PhD in Immunology, Immuno-Oncology or related field + 0-3 years of post-phD experience.
Proficiency in conventional immunological techniques such as primary T cell isolation, gene editing/transduction, expansion, ELISA, cell sorting and flow cytometry is required.
Broad knowledge in T cell antigen presentation, Dendritic cell, Macrophage, monocyte biology and their implications in TME ( eg. Liver, lung and colorectal cancer) is preferred.
Experience in CAR-T animal models, especially with utilizing in vivo CAR modalities such as engineered lentivirus or LNP/mRNA is a plus.
Experience in T cell tetramer analysis and clonal-expansion is a plus.
Experience working with Bispecific T cell engager is a plus.
Innovation in cell therapy space is preferred as evidenced by publications and patents.
Language: English

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.